Domain

Domain of unknown function DUF218 (IPR003848)

Short name: DUF218

Overlapping homologous superfamilies

None.

Domain relationships

None.

Description

This domain contains several highly conserved charged amino acids, suggesting this may be an enzymatic domain. It is found in Escherichia coli YdcF, which has been shown to bind S-adenosyl-L-methionine (AdoMet), but whose biochemical function has not been identified [PMID: 18393394]. It is also found in Escherichia coli SanA and Salmonella typhimurium SfiX, which are involved in vancomycin resistance [PMID: 8550448, PMID: 9738879]. SfiX may also be involved in murein synthesis.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
CDD
Pfam