Cytochrome C biogenesis protein, transmembrane domain (IPR003834)

Short name: Cyt_c_assmbl_TM_dom

Overlapping homologous superfamilies


Domain relationships



This entry represents the transmembrane domain of Cytochrome C biogenesis proteins also known as disulphide interchange proteins, such as DsbD from E. coli and DipZ from Mycobacterium. These proteins posses a protein disulphide isomerase like domain that is not found within the aligned region of this family.

DsbA and DsbC, periplasmic proteins of E. coli, are two key players involved in disulphide bond formation. DsbD generates a reducing source in the periplasm, which is required for maintaining proper redox conditions [PMID: 7628442]. DipZ is essential for maintaining cytochrome c apoproteins in the correct conformations for the covalent attachment of haem groups to the appropriate pairs of cysteine residues [PMID: 7623667].

GO terms

Biological Process

GO:0017004 cytochrome complex assembly
GO:0055114 oxidation-reduction process

Molecular Function

No terms assigned in this category.

Cellular Component

GO:0016020 membrane

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.