Family

(2R)-phospho-3-sulpholactate synthase, ComA (IPR003830)

Short name: ComA_synth

Family relationships

Description

Methanogenic archaea produce methane via the anaerobic reduction of acetate or single carbon compounds [PMID: 12440773]. Coenzyme M (CoM; 2-mercaptoethanesulphonic acid) serves as the terminal methyl carrier for this process. Previously thought to be unique to methanogenic archaea, CoM has also been found in methylotrophic bacteria.

Biosynthesis of CoM begins with the Michael addition of sulphite to phosphoenolpyruvate, forming 2-phospho-3-sulpholactate (PSL). This reaction is catalyzed by members of this family, PSL synthase (ComA) [PMID: 11830598]. Subsequently, PSL is dephosphorylated by phosphosulpholactate phosphatase (ComB) to form 3-sulpholactate [PMID: 11589710], which is then converted to 3-sulphopyruvate by L-sulpholactate dehydrogenase (ComC; EC:1.1.1.272) [PMID: 10850983]. Sulphopyruvate decarboxylase (ComDE; EC:4.1.1.79) converts 3-sulphopyruvate to sulphoacetaldehyde [PMID: 10940029]. Reductive thiolation of sulphoacetaldehyde is the final step.

GO terms

Biological Process

GO:0019295 coenzyme M biosynthetic process

Molecular Function

No terms assigned in this category.

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
Pfam
SUPERFAMILY