GTP cyclohydrolase FolE2/MptA (IPR003801)

Short name: GTP_cyclohydrolase_FolE2/MptA

Overlapping homologous superfamilies


Family relationships


This is a family of prokaryotic/archaeal proteins with type I GTP cyclohydrolase activity. GTP cyclohydrolase I is the first enzyme of the de novo tetrahydrofolate biosynthetic pathway present in bacteria, fungi, and plants, and encoded in Escherichia coli by the folE gene [PMID: 17032654]. FolE is Zinc 2+ dependent [PMID: 19767425].

In bacteria GTP cyclohydrolase FolE2 converts GTP to 7,8-dihydroneopterin triphosphate [PMID: 17032654]; while in the archaea GTP cyclohydrolase MptA converts GTP to 7,8-dihydro-D-neopterin 2',3'-cyclic phosphate, the first intermediate in the biosynthesis of coenzyme methanopterin [PMID: 17497938].

GO terms

Biological Process

No terms assigned in this category.

Molecular Function

GO:0003933 GTP cyclohydrolase activity

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.