Creatininase/formamide hydrolase (IPR003785)

Short name: Creatininase/forma_Hydrolase

Overlapping homologous superfamilies

Family relationships


This family includes the enzymes creatininase and 2-amino-5-formylamino-6-ribosylaminopyrimidin-4(3H)-one 5'-monophosphate deformylase, also known as formamide hydrolase.

Creatinase or creatinine amidohydrolase (EC: catalyses the hydrolysis of creatinine to creatine, which can then be metabolised to urea and sarcosine by creatinase (EC: Creatininase is a member of the urease-related amidohydrolase superfamily [PMID: 15003455]. Formamide hydrolase catalyzes the hydrolysis of the formamide of 2-amino-5-formylamino-6-ribosylamino-4(3H)-pyrimidinone 5'-monophosphate (FAPy) to form 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate (APy) (EC: [PMID: 19309161].

This family also includes 3-dehydro-scyllo-inosose hydrolase from the marine, hyperthermophilic bacterium Thermotoga maritima. The enzyme converts 3-dehydro-scyllo-inosose (diketo-inositol) to 5-dehydro-L-gluconate by catalysing ring-opening hydrolysis, and is a component of the myo-inositol degradation pathway. T. maritima is unable to grow on myo-inositol as a single carbon source [PMID: 23441918].

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.