COX15/CtaA family (IPR003780)

Short name: COX15/CtaA_fam

Overlapping homologous superfamilies


Family relationships


This is a family of integral membrane proteins. CtaA (also known as heme A synthase) is required for cytochrome aa3 oxidase assembly in Bacillus subtilis [PMID: 2549006]. COX15 is required for cytochrome c oxidase assembly in yeast [PMID: 9228094], and may also be involved in the synthesis of heme A [PMID: 12474143].

In some cases, heme A synthase is found fused to protoheme IX farnesyltransferase, an enzyme that converts protoheme IX to heme O.

GO terms

Biological Process

GO:0006784 heme a biosynthetic process
GO:0055114 oxidation-reduction process

Molecular Function

GO:0016627 oxidoreductase activity, acting on the CH-CH group of donors

Cellular Component

GO:0016021 integral component of membrane

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.