YcaO-like domain (IPR003776)

Short name: YcaO-like_dom

Overlapping homologous superfamilies


Domain relationships



This domain comprises the whole of a protein in Methanocaldococcus jannaschii and Methanobacterium thermoautotrophicum, all but the N-terminal 60 residues from a protein of Mycobacterium tuberculosis, and all but the C-terminal 180 residues from a protein in Haemophilus influenzae and Escherichia coli, among proteins from published complete genomes. This domain contains a conserved ATP-binding pocket [PMID: 25129028].

The domain can be found in Escherichia coli YcaO, which is known to be involved in beta-methylthiolation of ribosomal protein S12 [PMID: 21169565]. YcaO-like domains have been shown to be catalytically active, and to use ATP to activate amide backbones during peptide cyclodehydrations [PMID: 22522320]. It is likely to be involved in post-translational modification (PTM) of amino acid residues.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
PROSITE profiles