N-acetylglucosamine-6-phosphate deacetylase (IPR003764)

Short name: GlcNAc_6-P_deAcase

Overlapping homologous superfamilies

Family relationships



Three enzymes are required for N-acetylglucosamine (NAG) utilization in Escherichia coli: enzyme IInag (gene nagE), N-acetylglucosamine-6-phosphate deacetylase (gene nagA), and glucosamine-6-phosphate isomerase (gene nagB) [PMID: 2190615]. This entry represents the N-acetylglucosamine-6-phosphate deacetylases (NagA), EC: [PMID: 9301118].

NagA catalyzes the hydrolysis of the N-acetyl group of N-acetyl-glucosamine-6-phosphate (GlcNAc-6-P) to glucosamine 6-phosphate and acetate. This is the first committed step in the biosynthetic pathway to amino-sugar-nucleotides, which is needed for cell wall peptidoglycan (murein) and teichoic acid biosynthesis. Deacetylation of N-acetylglucosamine is also important in lipopolysaccharide synthesis and cell wall recycling [PMID: 11395446].

GO terms

Biological Process

GO:0006044 N-acetylglucosamine metabolic process

Molecular Function

GO:0008448 N-acetylglucosamine-6-phosphate deacetylase activity

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.