HPr(Ser) kinase/phosphorylase (IPR003755)

Short name: HPr(Ser)_kin/Pase

Overlapping homologous superfamilies


Family relationships



This entry represents the bifunctional HPr serine kinase/phosphorylase (HprK/P). It catalyses the phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). It also catalyses thedephosphorylation of seryl-phosphorylated HPr (P-Ser-HPr). The two antagonistic activities of HprK/P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. HprK/P is the sensor in a multicomponent phosphorelay system that controls catabolite repression, sugar transport and carbon metabolism in Gram-positive bacteria [PMID: 9987110, PMID: 15023355].

GO terms

Biological Process

GO:0000160 phosphorelay signal transduction system
GO:0006109 regulation of carbohydrate metabolic process

Molecular Function

GO:0005524 ATP binding
GO:0000155 phosphorelay sensor kinase activity

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.