Family

SOS response associated peptidase (SRAP) (IPR003738)

Short name: SRAP

Family relationships

None.

Description

The SRAP family functions as a DNA-associated autoproteolytic switch that recruits diverse repair enzymes onto DNA damage. The human SRAP member (Q96FZ2) has been shown to bind specifically to DNA with 5-hydroxymethylcytosine, 5-formylcytosine and 5-carboxycytosine. It was predicted to be a sensor for these oxidized bases generated by the TET (tetrahedral aminopeptidase of the M42 family) enzymes from methylcytosine. Hence, its autoproteolytic activity might help it act as a switch that recruits DNA repair enzymes to remove these oxidized methylcytosine species as part of the DNA demethylation pathway downstream of the TET enzymes [PMID: 23945014].

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
Pfam
GENE3D
PANTHER
SUPERFAMILY