Family

Metal-sensitive transcriptional repressor (IPR003735)

Short name: Metal_Tscrpt_repr

Family relationships

None.

Description

This is a family of metal-sensitive repressors, involved in resistance to metal ions. Members of this family bind copper, nickel or cobalt ions via conserved cysteine and histidine residues. In the absence of metal ions, these proteins bind to promoter regions and repress transcription. When bound to metal ions they are unable to bind DNA, leading to transcriptional derepression [PMID: 17143269, PMID: 20395270, PMID: 17186148, PMID: 17293508, PMID: 16956381].

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
Pfam