Metal-sensitive transcriptional repressor (IPR003735)

Short name: Metal_Tscrpt_repr

Overlapping homologous superfamilies

Family relationships



This is a family of metal-sensitive repressors, involved in resistance to metal ions. Members of this family bind copper, nickel or cobalt ions via conserved cysteine and histidine residues. In the absence of metal ions, these proteins bind to promoter regions and repress transcription. When bound to metal ions they are unable to bind DNA, leading to transcriptional derepression [PMID: 17143269, PMID: 20395270, PMID: 17186148, PMID: 17293508, PMID: 16956381].

GO terms

Biological Process

GO:0006355 regulation of transcription, DNA-templated

Molecular Function

GO:0003677 DNA binding
GO:0046872 metal ion binding

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.