Family

D-aminoacyl-tRNA deacylase DTD (IPR003732)

Short name: Daa-tRNA_deacyls_DTD

Family relationships

None.

Description

This family consists of D-aminoacyl-tRNA deacylase DTD, also known as D-Tyr-tRNA(Tyr) deacylase. It is an enzyme that cleaves misacetylated D-aminoacyl-tRNA molecules into free tRNAs and D-amino acids [PMID: 11568181, PMID: 25441601]. Cell growth inhibition by several D-amino acids can be explained by an in vivo production of D-aminoacyl-tRNA molecules.

The enzyme is found in bacteria and in eukaryotes but not in archea. It has a beta barrel-like fold structure and forms homodimers in which two surface cavities serve as the active site for tRNA binding [PMID: 10918062, PMID: 10766779, PMID: 10383414].

GO terms

Biological Process

No terms assigned in this category.

Molecular Function

GO:0051499 D-aminoacyl-tRNA deacylase activity
GO:0002161 aminoacyl-tRNA editing activity

Cellular Component

GO:0005737 cytoplasm

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
CDD
Pfam
HAMAP
PANTHER
TIGRFAMs