Family

D-tyrosyl-tRNA(Tyr) deacylase (IPR003732)

Short name: DTyrtRNA_deacyls

Family relationships

None.

Description

This family comprises of several D-Tyr-tRNA(Tyr) deacylase proteins. Cell growth inhibition by several d-amino acids can be explained by an in vivo production of d-aminoacyl-tRNA molecules. Escherichia coli and yeast cells express an enzyme, d-Tyr-tRNA(Tyr) deacylase, capable of recycling such d-aminoacyl-tRNA molecules into free tRNA and d-amino acid. Accordingly, upon inactivation of the genes of the above deacylases, the toxicity of d-amino acids increases. Orthologues of the deacylase are found in many cells [PMID: 11568181].

GO terms

Biological Process

GO:0019478 D-amino acid catabolic process

Molecular Function

GO:0016788 hydrolase activity, acting on ester bonds

Cellular Component

GO:0005737 cytoplasm

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
HAMAP
PANTHER
TIGRFAMs
Pfam