Family

Multi-copper polyphenol oxidoreductase (IPR003730)

Short name: Cu_polyphenol_OxRdtase

Family relationships

None.

Description

Laccases are multi-copper oxidoreductases able to oxidise a wide variety of phenolic and non-phenolic compounds and are widely distributed among both prokaryotes and eukaryotes. There are two main active catalytic sites with conserved histidines that are capable of binding four copper atoms [PMID: 16740638].

This family consists of polyphenol oxidases with laccase activity from bacteria. They may constitute a new laccase subfamily, as they lack sequence relatedness to known laccases [PMID: 16740638]. This family also includes laccase domain-containing protein 1 (Lacc1, FAMIN), which is thought to be a central regulator of immunometabolic function in humans [PMID: 27478939, PMID: 28593945].

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
CDD
PANTHER
Pfam
TIGRFAMs