Family

Pantoate-beta-alanine ligase (IPR003721)

Short name: Pantoate_ligase

Family relationships

Description

D-Pantothenate is synthesized via four enzymes from ketoisovalerate, which is an intermediate of branched-chain amino acid synthesis [PMID: 10223988]. Pantoate-beta-alanine ligase, also know as pantothenate synthase, (PanC; EC:6.3.2.1) catalyzes the formation of pantothenate from pantoate and alanine in the pantothenate biosynthesis pathway [PMID: 8760912].

PanC belongs to a large superfamily of nucleotidyltransferases that includes ATP sulfurylase (ATPS), phosphopantetheine adenylyltransferase (PPAT), and the amino-acyl tRNA synthetases. The enzymes of this family are structurally similar and share a dinucleotide-binding domain [PMID: 15565250, PMID: 7479698, PMID: 374975, PMID: 7037743, PMID: 10417331].

GO terms

Biological Process

GO:0015940 pantothenate biosynthetic process

Molecular Function

GO:0004592 pantoate-beta-alanine ligase activity

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
TIGRFAMs
PANTHER
CDD
HAMAP
Pfam