Domain

Peptidase M15B (IPR003709)

Short name: Pept_M15B

Domain relationships

Description

These proteins are metallopeptidases belonging to MEROPS peptidase family M15 (clan MD), subfamily M15B (vanY D-Ala-D-Ala carboxypeptidase).

Acquired VanA- and VanB-type glycopeptide resistance in enterococci is due to synthesis of modified peptidoglycan precursors terminating in D-lactate. As opposed to VanA-type strains which are resistant to both vancomycin and teicoplanin, VanB-type strains remain teicoplanin susceptible [PMID: 8631706]. The vanY gene was necessary for synthesis of the vancomycin-inducible D,D-carboxypeptidase EC:3.4.16.4 activity previously proposed to be responsible for glycopeptide resistance. However, this activity was not required for peptidoglycan synthesis in the presence of glycopeptides [PMID: 1398115].

GO terms

Biological Process

GO:0006508 proteolysis

Molecular Function

GO:0008233 peptidase activity

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
Pfam