Family

DNA double-strand break repair protein Mre11 (IPR003701)

Short name: Mre11

Family relationships

None.

Description

Mre11 and Rad50 are two proteins required for DNA repair and meiosis-specific double-strand break formation in Saccharomyces cerevisiae. Mre11 by itself has 3' to 5' exonuclease activity that is increased when Mre11 is in a complex with Rad50 [PMID: 9651580].

These eukaryotic proteins contain one metallo-phosphoesterase domain followed by an Mre11 DNA-binding domain. S. cerevisiae Mre11 is required for DNA repair and meiosis-specific double-strand break (DSB) formation [PMID: 7789757] and has both 3' to 5' exonuclease activity (which increases when in complex with Rad50) and endonuclease activity. The N-terminal phosphoesterase domain is required for DSB repair, and the carboxyl-terminal dsDNA-binding domain is essential during meiosis for chromatin modification and DSB formation [PMID: 9799249]. Schizosaccharomyces pombe rad32 is required for repair of double strand breaks and recombination [PMID: 7885834].

GO terms

Biological Process

GO:0006302 double-strand break repair

Molecular Function

GO:0008408 3'-5' exonuclease activity
GO:0004519 endonuclease activity

Cellular Component

GO:0030870 Mre11 complex

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
PIRSF
TIGRFAMs