Family

Maf-like protein (IPR003697)

Short name: Maf

Family relationships

Description

The Maf protein of Bacillus subtilis shares substantial amino acid sequence identity with Escherichia coli YhdE (previously known as OrfE) [PMID: 8387996]. Maf-like proteins are conserved in bacteria, archaea, and eukaryotes. Maf proteins have been implicated in cell division arrest [PMID: 21564336]. It has also been proposed that they belong to a family of house-cleaning nucleotide hydrolyzing enzymes which prevent the incorporation of noncanonical nucleotides into cellular DNA [PMID: 16359314]. Maf proteins exhibit nucleotide pyrophosphatase activity against canonical and modified nucleotides, which might represent a molecular mechanism for this dual role in cell division arrest and in house-cleaning [PMID: 24210219].

GO terms

Biological Process

No terms assigned in this category.

Molecular Function

GO:0047429 nucleoside-triphosphate diphosphatase activity

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
PIRSF
TIGRFAMs
Pfam
CDD
HAMAP