Family

Mitochodrial transcription termination factor (IPR003690)

Short name: MTERF

Family relationships

None.

Description

This entry represents the mitochondrial transcription termination factors (MTERFs). In humans four MTERFs have been identified (MTERF1-4). MTERF1 was first identified as a factor responsible for terminating heavy strand transcription at a specific site at the leu-tRNA, thereby modulating the ratio of mitochondrial ribosomal RNA to mRNA [PMID: 2752429]. Later, MTERF1 was found to stimulate transcriptional initiation [PMID: 19366610] and appeared to be in the control of mitochondrial replication pausing [PMID: 17884915]. From a structural study, it binds to dsDNA containing the termination sequence and unwinds the DNA molecule, promoting base eversion, which is critical for transcription termination [PMID: 20550934].

GO terms

Biological Process

GO:0006355 regulation of transcription, DNA-templated

Molecular Function

GO:0003690 double-stranded DNA binding

Cellular Component

GO:0005739 mitochondrion

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
SMART
Pfam