Type IV secretion system protein TraG/VirD4 (IPR003688)

Short name: TraG/VirD4

Overlapping homologous superfamilies

Family relationships


This entry represents type IV secretion system proteins TraG and VirD4. TraG-like proteins are potential NTP hydrolases (NTPases) that are essential for DNA transfer in bacterial conjugation. They are thought to mediate interactions between the DNA-processing (Dtr) and the mating pair formation (Mpf) systems [PMID: 11976307, PMID: 10692358]. TraG-like proteins also function as essential components of type IV secretion systems of several bacterial pathogens. TraG is essential for DNA transfer in bacterial conjugation [PMID: 11976307]. Agrobacterium tumefaciens VirD4 is essential for DNA transfer to plants [PMID: 11952902]. VirD has been shown to have topoisomerase activity in vitro [PMID: 2541431].

GO terms

Biological Process

GO:0009291 unidirectional conjugation

Molecular Function

No terms assigned in this category.

Cellular Component

GO:0016020 membrane

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.