Family

Aminoglycoside N(3)-acetyltransferase (IPR003679)

Short name: Amioglycoside_AcTrfase

Family relationships

None.

Description

This family consists of bacterial aminoglycoside N(3)-acetyltransferases (EC:2.3.1.81) that catalyse the reaction [PMID: 1761222]: Acetyl-Co + a 2-deoxystreptamine antibiotic = CoA + N3'-acetyl-2-deoxystreptamine antibiotic The enzyme can use a range of antibiotics with 2-deoxystreptamine rings as acceptor for its acetyltransferase activity, this inactivates and confers resistance to gentamicin, kanamycin, tobramycin, neomycin and apramycin amongst others. For the kanamycin group antibiotics acetylation occurred at the 3"-amino group in arbekacin and amikacin, and at the 3-amino group in dibekacin as in the case of kanamycin reflecting the effect of the (S)-4-amino-2-hydroxybutyryl side chain which is present in arbekacin and amikacin, but absent in dibekacin and kanamycin [PMID: 9766465].

GO terms

Biological Process

GO:0046677 response to antibiotic

Molecular Function

GO:0046353 aminoglycoside 3-N-acetyltransferase activity

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
PANTHER
Pfam