CAAX prenyl protease 2 (IPR003675)

Short name: CAAX_protease_2

Overlapping homologous superfamilies


Family relationships


This family includes eukaryotic type II CAAX prenyl proteases and their related bacterial and archaeal homologues. After a isoprenyl group is attached to the Cys residue in the C-terminal CAAX motif of a protein to attach it to the membrane, the AAX tripeptide is removed by one of the CAAX prenyl proteases. The family contains the Q03530 CAAX prenyl protease [PMID: 9065405].

A member of this family was originally identified as the product of an open reading frame (orfX) upstream of two genes (abiGi and abiGii) involved in an abortive infection system, hence it was previously known as ABI. However, inactivation of this CPBP member (OrfX) suggests that it is not involved in the abortive infection mechanism [PMID: 21570408]. This family also includes lysostaphin resistance protein A [PMID: 16923896].

GO terms

Biological Process

No terms assigned in this category.

Molecular Function

No terms assigned in this category.

Cellular Component

GO:0016020 membrane

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.