Krueppel-associated box-related (IPR003655)

Short name: Krueppel-associated_box-rel

Overlapping homologous superfamilies

Domain relationships


This domain of about 63 amino acid residues is related to the Krueppel-associated box (KRAB) domain and has been identified in the N-terminal ends of proteins belonging to the SSX family [PMID: 7539744, PMID: 8697803, PMID: 9378559]. Proteins of the SSX family lack the C2H2-type zinc finger which is invariably found in proteins containing the KRAB domain. The KRAB-related domains show greatest homology to the KRAB A subdomain and contain a high proportion of the amino acids which are usually conserved between the KRAB A subdomains of zinc finger proteins [PMID: 7539744].

Although the KRAB-related domains of SSX1 and SSX2 contribute to the repressive activity of these proteins, transcriptional repression is mainly mediated by a region located in their C terminus. Hence, unlike the KRAB domain, the KRAB-related domain is only a weak transcriptional repression domain. In addition the KRAB-related domain is unable to interact with the KAP-1/TIF1-beta protein which appears to function as a universal corepressor for KRAB domain proteins [PMID: 9788446].

GO terms

Biological Process

GO:0006355 regulation of transcription, DNA-templated

Molecular Function

No terms assigned in this category.

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
PROSITE profiles