Parathyroid hormone-related protein (IPR003626)

Short name: PTH-rel

Overlapping homologous superfamilies


Family relationships


Parathyroid hormone-related protein (PTH-rP) is structurally related to parathyroid hormone (PTH) [PMID: 2682846] and seems to play a physiological role in lactation, possibly as a hormone for the mobilisation and/or transfer of calcium to the milk. It also regulates chondrocytic differentiation and bone formation [PMID: 11760831].

This family also includes the zebrafish PTH family member Pth4, unique to noneutherian vertebrates, which is a regulator of bone mineral accrual acting through phosphate homeostasis [PMID: 28148780].


GO terms

Biological Process

GO:0030282 bone mineralization

Molecular Function

GO:0005179 hormone activity

Cellular Component

GO:0005576 extracellular region

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.