Parathyroid hormone-related protein (IPR003626)
Short name: PTH-rel
Overlapping homologous superfamilies
- Parathyroid hormone/parathyroid hormone-related protein (IPR001415)
- Parathyroid hormone-related protein (IPR003626)
Parathyroid hormone-related protein (PTH-rP) is structurally related to parathyroid hormone (PTH) [PMID: 2682846] and seems to play a physiological role in lactation, possibly as a hormone for the mobilisation and/or transfer of calcium to the milk. It also regulates chondrocytic differentiation and bone formation [PMID: 11760831].
This family also includes the zebrafish PTH family member Pth4, unique to noneutherian vertebrates, which is a regulator of bone mineral accrual acting through phosphate homeostasis [PMID: 28148780]..
- PTHR17223 (PTHR17223)