Snake three-finger toxin (IPR003571)

Short name: Snake_3FTx

Overlapping homologous superfamilies


Family relationships


Three finger toxins (3FTx) constitute an important super-family of snake venom proteins. All have three beta stranded loops resembling threefingers, emerging from a globular core and stabilised by four conserved disulfide bridges. They are diverse in their biological functions, and include neurotoxins, cardiotoxins, cytotoxins, fasciculins, platelet-aggregation inhibitors and specific ion-channel blockers [PMID: 24966535].

Neurotoxins interfere with cholinergic transmission at post synaptic sites in the peripheral and central nervous systems and consist of alpha-neurotoxins, kappa-neurotoxins and muscarinic toxins. Cardiotoxins are the second largest group and are only found in cobra venoms [PMID: 3277206]. Acetylcholine receptors are blocked by alpha-neurotoxin [PMID: 1939183] and cardiotoxins (cytotoxins) [PMID: 2126462]. Fasciculins (cytotoxins) inhibit L-type calcium-channel blockers [PMID: 7727450].

GO terms

Biological Process

GO:0009405 pathogenesis

Molecular Function

GO:0090729 toxin activity

Cellular Component

GO:0005576 extracellular region

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.