Family

7,8-dihydro-8-oxoguanine triphosphatase (IPR003563)

Short name: OxG-triPHTase

Family relationships

None.

Description

The enzyme 8-oxo-7,8-dihydrodeoxyguanosine triphosphatase (8-oxo-dGTPase) is present in a variety of organisms, where it plays an important role in the control of spontaneous mutagenesis [PMID: 7586133]. The enzyme degrades 8-oxoguanine- containing deoxyribonucleoside triphosphate, a potentially mutagenic substrate for DNA synthesis, to the corresponding monophosphate, thereby preventing misincorporation of 8-oxo-dGTP into DNA [PMID: 7586133].

8-oxo-dGTPase is an 18kDa protein containing 156 amino acid residues. The amino acid sequence shares a degree of similarity with the MutT domain of the Escherichia coli MutT protein, which has a distinct 8-oxo-dGTPase activity [PMID: 8226881]. When human cDNA is expressed in E. coli mutT- mutant cells, there is a significant amount of 8-oxo-dGTPase activity and a reduced frequency of spontaneous mutation. Human 8-oxo-dGTPase is thought to protect genetic information from the untoward effects of endogenous oxygen radicals [PMID: 8226881].

GO terms

Biological Process

GO:0006281 DNA repair

Molecular Function

GO:0008413 8-oxo-7,8-dihydroguanosine triphosphate pyrophosphatase activity

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
PRINTS