Mutator MutX protein (IPR003562)

Short name: Mutator_MutX_prot

Overlapping homologous superfamilies

Family relationships



Like MutT (IPR003561), MutX protein hydrolyses all canonical nucleoside triphosphates at different rates, with a preference for dGTP, yielding nucleoside monophosphates and inorganic pyrophosphate [PMID: 8163538]. Despite the similarity in enzymatic activity, the two proteins have distinct primary and quaternary structures. Their sequences share only a small region of similarity (the MutT domain), and under the same conditions in which MutT exists as a monomer in solution, MutX behaves as a trimer [PMID: 8163538].

GO terms

Biological Process

GO:0006281 DNA repair

Molecular Function

GO:0008413 8-oxo-7,8-dihydroguanosine triphosphate pyrophosphatase activity

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.