Family

2,3-dihydro-2,3-dihydroxybenzoate dehydrogenase (IPR003560)

Short name: DHB_DH

Family relationships

None.

Description

The absence of free iron molecules in the surrounding environment triggers transcription of gene clusters that encode both siderophore-synthesis enzymes, and receptors that recognise iron-bound siderophores [PMID: 2521621]. Classic examples are the enterobactin/enterochelin clusters found in Escherichia coli and Salmonella, although similar moieties in other pathogens have been identified. The enzymic machinery that produces vibrionectin in Vibrio cholerae is such a homologue [PMID: 9371453].

EntA, a 2,3-dihydro-2,3-dihydroxybenzoate dehydrogenase enzyme, is the third enzyme in the biosynthesis of 2,3-dihydroxybenzoic acid (DHB) from chorismate in Escherichia coli. It converts isochorismate to DHB, used for the synthesis of iron chelator enterobactin. Bacillus subtilis possesses similar genes involved in siderophore biosynthesis [PMID: 8921902]. Deletion studies involving EntA-mutants have shown that it is essential for virulence [PMID: 2521622].

GO terms

Biological Process

GO:0055114 oxidation-reduction process
GO:0019290 siderophore biosynthetic process

Molecular Function

GO:0008667 2,3-dihydro-2,3-dihydroxybenzoate dehydrogenase activity

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
PRINTS
TIGRFAMs