Cytolethal distending toxin A/C (IPR003558)

Short name: CDtoxinA/C

Family relationships


Escherichia coli, Haemophilus spp and Campylobacter spp. all produce a toxin that is seen to cause distension in certain cell lines [PMID: 8112838, PMID: 10203548], which eventually disintegrate and die. This novel toxin, termed cytolethal distending toxin (cdt), has three subunits: A, B and C. Their sizes are approx. 27.7, 29.5 and 19.9kDa respectively [PMID: 8112838], and they appear to be entirely novel [PMID: 10203548].

Further research on the complete toxin has revealed that it blocks the cell cycle at stage G2, through inactivation of the cyclin-dependent kinase Cdk1, and without induction of DNA breaks. This leads to multipolar abortive mitosis and micronucleation, associated with centrosomal amplification [PMID: 10777111]. The roles of each subunit are unclear, but it is believed that they have separate roles in pathogenicity.

This entry represents the A and C subunits.

GO terms

Biological Process

GO:0009405 pathogenesis

Molecular Function

No terms assigned in this category.

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.