Family

Claudin-11 (IPR003555)

Short name: Claudin11

Overlapping homologous superfamilies

None.

Family relationships

Description

Claudins form the paracellular tight junction seal in epithelial tissues. In humans, 24 claudins (claudin 1-24) have been identified. Their ability to polymerise and form strands is affected by the cell types [PMID: 21372174, PMID: 20188437, PMID: 24665401]. They can also form heteropolymers with each other within and between tight junction strands [PMID: 10562289]. Most of the claudins (claudin-12 being the exception) have a C-terminal PDZ-binding motif that can interact with other PDZ domain proteins, such as scaffolding protein, ZO-1, -2 and -3 [PMID: 24665401]. They also interact with non-tight junction proteins, such as cell adhesion proteins EpCam and tetraspanins and the signaling proteins, ephrin A and B and their receptors, EphA and EphB [PMID: 24665401].

Claudin-11 was originally termed oligodendrocyte-specific protein (OSP). It was reclassified as claudin-11 due to its sequence similarity to claudins and its ability to form TJ strands in transfected fibroblasts. Claudin-11 expression is highly regulated during development and it has been postulated that it may play an important role in the growth and differentiation of oligodendrocytes and other cells outside the CNS [PMID: 11309411].

GO terms

Biological Process

No terms assigned in this category.

Molecular Function

GO:0005198 structural molecule activity

Cellular Component

GO:0005923 bicellular tight junction

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
PANTHER
PRINTS