Claudin-5 (IPR003551)

Short name: Claudin5

Overlapping homologous superfamilies


Family relationships


Claudins form the paracellular tight junction seal in epithelial tissues. In humans, 24 claudins (claudin 1-24) have been identified. Their ability to polymerise and form strands is affected by the cell types [PMID: 21372174, PMID: 20188437, PMID: 24665401]. They can also form heteropolymers with each other within and between tight junction strands [PMID: 10562289]. Most of the claudins (claudin-12 being the exception) have a C-terminal PDZ-binding motif that can interact with other PDZ domain proteins, such as scaffolding protein, ZO-1, -2 and -3 [PMID: 24665401]. They also interact with non-tight junction proteins, such as cell adhesion proteins EpCam and tetraspanins and the signaling proteins, ephrin A and B and their receptors, EphA and EphB [PMID: 24665401].

Claudin-5 was originally termed lung-specific membrane protein, brain endothelial cell clone 1 protein (BEC1), and transmembrane protein deleted in velo-cardio-facial syndrome (TMVCF). It was reclassified as claudin-5 on the basis of cDNA sequence similarity with claudins-1 and -2, and antibody studies that showed it to be expressed at tight junctions [PMID: 9892664]. Claudin-5 may play an important role in development, since the gene is frequently deleted in velo-cardio-facial/DiGeorge syndrome patients [PMID: 9192844].

GO terms

Biological Process

No terms assigned in this category.

Molecular Function

GO:0005198 structural molecule activity

Cellular Component

GO:0005923 bicellular tight junction

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.