Family

Claudin-3 (IPR003549)

Short name: Claudin3

Family relationships

Description

Claudins form the paracellular tight junction seal in epithelial tissues. In humans, 24 claudins (claudin 1-24) have been identified. Their ability to polymerise and form strands is affected by the cell types [PMID: 21372174, PMID: 20188437, PMID: 24665401]. They can also form heteropolymers with each other within and between tight junction strands [PMID: 10562289]. Most of the claudins (claudin-12 being the exception) have a C-terminal PDZ-binding motif that can interact with other PDZ domain proteins, such as scaffolding protein, ZO-1, -2 and -3 [PMID: 24665401]. They also interact with non-tight junction proteins, such as cell adhesion proteins EpCam and tetraspanins and the signaling proteins, ephrin A and B and their receptors, EphA and EphB [PMID: 24665401].

Claudin-3 was originally termed rat ventral prostate 1 protein (RVP1), and Clostridium perfringens enterotoxin receptor 2 (CPETR2). It was reclassified as claudin-3 on the basis of cDNA similarity with claudins-1 and -2, and antibody studies that showed it to be expressed at tight junctions [PMID: 9892664].

GO terms

Biological Process

No terms assigned in this category.

Molecular Function

GO:0005198 structural molecule activity

Cellular Component

GO:0005923 bicellular tight junction

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
PRINTS