Claudin-1 (IPR003548)

Short name: Claudin1

Family relationships


Claudins form the paracellular tight junction seal in epithelial tissues. In humans, 24 claudins (claudin 1-24) have been identified. Their ability to polymerise and form strands is affected by the cell types [ , , ]. They can also form heteropolymers with each other within and between tight junction strands [ ]. Most of the claudins (claudin-12 being the exception) have a C-terminal PDZ-binding motif that can interact with other PDZ domain proteins, such as scaffolding protein, ZO-1, -2 and -3 [ ]. They also interact with non-tight junction proteins, such as cell adhesion proteins EpCam and tetraspanins and the signaling proteins, ephrin A and B and their receptors, EphA and EphB [ ].

Claudin-1 was the first member of the claudin family to be identified as a tight junction component [PMID: 9647647]. The human isoform of claudin-1 was originally termed senescence-associated epithelial membrane protein 1 (SEMP1) [PMID: 9931503], but has since been reclassified.

GO terms

Biological Process

No terms assigned in this category.

Molecular Function

GO:0005198 structural molecule activity

Cellular Component

GO:0005923 tight junction

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.