Macrophage scavenger receptor (IPR003543)

Short name: Macro_scav_rcpt

Overlapping homologous superfamilies


Domain relationships



The egg peptide speract receptor is a transmembrane glycoprotein of about 500 amino acids [PMID: 2538832]. Topologically, it comprises a large extracellular domain of about 450 residues, followed by a transmembrane domain and a short cytoplasmic region of about 12 amino acids. The extracellular domain contains 4 repeats of a well-conserved region, which spans 115 amino acids and contains 6 conserved cysteines. A similar domain is also found towards the C terminus of macrophage scavenger receptor type I [PMID: 1978939], a membrane glycoprotein implicated in the pathologic deposition of cholesterol in arterial walls during artherogenesis, and in the CD5 glycoprotein, which acts as a receptor in regulating T-cell proliferation.

The type I and type II human scavenger receptors are similar to their bovine, rabbit and murine counterparts. They consist of 6 domains: cytoplasmic (I); membrane-spanning (II); spacer (III); alpha-helical coiled- coil (IV); collagen-like (V); and a type-specific C-terminal (VI) [PMID: 2251254]. Immunohistochemical studies have indicated the presence of scavenger receptors in the macrophages of lipid-rich atherosclerotic lesions, suggesting the involvement of these receptors in atherogenesis [PMID: 2251254].

The macrophage scavenger receptor is trimeric and has unusual ligand-binding properties [PMID: 2300204]. The trimeric structure of the bovine type I scavenger receptor contains 3 extracellular C-terminal cysteine-rich domains connected to the transmembrane domain by a long fibrous stalk. The stalk structure, which consists of an alpha-helical coiled coil and a collagen-like triple helix, has not previously been observed in an integral membrane protein [PMID: 2300204].

GO terms

Biological Process

GO:0006898 receptor-mediated endocytosis

Molecular Function

GO:0005044 scavenger receptor activity

Cellular Component

GO:0016020 membrane

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.