Cytolethal distending toxin B (IPR003539)

Short name: CD_toxinB

Overlapping homologous superfamilies

Family relationships



cytolethal distending toxin (CDT) is a secreted protein toxin produced by a number of Gram-negative disease-causing bacteria. CDT causes cell cycle arrest and eventual cell death in eukaryotic cells, as a result of chromosomal DNA damage caused by the catalytic, DNase I-like, CdtB subunit. Bacterial CDTs are generally comprised of three subunits, CdtA, -B and -C [PMID: 11583839]. CdtB is translocated into the host cell, where it acts as a genotoxin [PMID: 15164065, PMID: 15713603]. CdtA and CdtC are needed for cell surface binding and cellular entry, and it is likely that they remain associated with the membrane, when CdtB is internalized. CdtB enters the target nucleus via nuclear translocation signal domain(s) [PMID: 12947116].

GO terms

Biological Process

GO:0009405 pathogenesis

Molecular Function

No terms assigned in this category.

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.