Conserved Site

Short hematopoietin receptor, family 2, conserved site (IPR003532)

Short name: Short_hematopoietin_rcpt_2_CS


A number of receptors for lymphokines, hematopoietic growth factors and growth hormone-related molecules have been found to share a common binding domain. These receptors are designated as hematopoietin receptors [PMID: 1400369] and the corresponding ligands as hematopoietins. Further, hematopoietins have been subdivided into two major structural groups: large (long) and small (short) hematopoietins.

One subset of individual receptor chains that are part of receptor complexes for small hematopoietins contain common structural elements: an extracellular receptor domain that contains an immunoglobulin-like region at the N-terminal end; a transmembrane domain; and a short cytoplasmic domain. They define a structural subgroup containing the following chains:

  • Granulocyte/macrophage colony stimulating factor receptor alpha (GMCSFRA)
  • Interleukin-3 receptor alpha chain (IL3RA)
  • Interleukin-5 receptor alpha chain (IL5RA)
  • Interleukin-13 receptor alpha-1 chain (IL13RA1)
  • Interleukin-13 receptor alpha-2 chain (IL13RA2)

GMCSFRA, IL3RA or IL5RA chains of this subgroup bind to their cognate cytokines: GM-CSF, IL-3 and IL-5, with a common beta chain, KH97/AIC2B [PMID: 1913811]. Either IL13RA1 chain or IL13RA2 chain form the IL13R complex together with IL4RA chain. IL-4 can compete with IL-13 to bind to either IL13R form [PMID: 8552669].

GO terms

Biological Process

No terms assigned in this category.

Molecular Function

GO:0004896 cytokine receptor activity

Cellular Component

GO:0016020 membrane

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
PROSITE patterns