Conserved Site

Short hematopoietin receptor, family 1, conserved site (IPR003531)

Short name: Hempt_rcpt_S_F1_CS

Description

A number of receptors for lymphokines, hematopoietic growth factors and growth hormone-related molecules have been found to share a common binding domain. These receptors are designated as hematopoietin receptors [PMID: 1400369] and the corresponding ligands as hematopoietins. Further, hematopoietins have been subdivided into two major structural groups: Large/long and small/short hematopoietins.

One subset of individual receptor chains that are part of receptor complexes for small hematopoietins are structurally related such that their extracellular parts strictly contain the 200 amino-acids hematopoietin domain (duplicated in IL-3/-5/GM-CSF beta chain receptors KH97/AIC2B and AIC2A). They define a structural subgroup containing the following chains: Interleukin-2 receptor beta chain (IL2RB), Interleukin-2 receptor common gamma chain (IL2RG), Interleukin-3 receptor beta chain (AIC2A), Interleukin-3/-5/GM-CSF receptor common beta chain (KH97/AIC2B), Interleukin-4 receptor alpha chain (IL4RA), Interleukin-7 receptor alpha chain (IL7RA), Interleukin-9 receptor alpha chain (IL9RA).

A schematic representation of the structure of these receptors is shown below:

 
 +----------------------------------------xxxxxxx---------------------------+
 | C C       C  C  Extracellular          XXXXXXX   Cytoplasmic             |
 +-|-|-------|--|-------------------------xxxxxxx---------------------------+
   | |       |  |                      Transmembrane
   +-+       +--+
 

IL4RA, IL7RA and IL9RA are specific alpha chain receptors for IL-4, IL-7 and IL-9 respectively, whereas IL2RB is common to IL-2 and IL-15 (IL2RA and IL15RA are not members of the hematopoietin receptor superfamily). IL2RG is part of IL-2, IL-15, IL-7, IL-9 and IL-4 form I receptor complexes [PMID: 7946053]. KH97/AIC2B chain is part of GM-CSF, IL-3 and IL-5 receptor complexes and in the mouse, AIC2B can be substituted by AIC2A, an IL-3 specific beta chain receptor [PMID: 1913811]. Together with either IL13RA1 or IL13RA2, IL4RA is also part of the IL-13 receptor complex for which IL-4 can compete with IL-13 (IL-4 receptor complex form II) [PMID: 8552669].

GO terms

Biological Process

No terms assigned in this category.

Molecular Function

GO:0004896 cytokine receptor activity

Cellular Component

GO:0016020 membrane

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
PROSITE patterns