Conserved Site

Long hematopoietin receptor, Gp130 family 2, conserved site (IPR003529)

Short name: Hematopoietin_rcpt_Gp130_CS

Description

A number of receptors for lymphokines, hematopoietic growth factors and growth hormone-related molecules have been found to share a common binding domain. These receptors are designated as hematopoietin receptors [PMID: 1400369] and the corresponding ligands as hematopoietins. Further, hematopoietins have been subdivided into two major structural groups: Large/long and small/short hematopoietins.

One subset of individual receptor chains that are part of receptor complexes for large hematopoietins contain common structural elements in their extracellular parts: an immunoglobin-like domain, an hematopoietin-receptor domain, and 3 fibronectin type-III domains (2 in the leptin receptor). This subgroup was designated as "Gp130 family of receptors" [PMID: 8999038] and contains the following chains: Leptin receptor (LPTR), Granulocyte colony stimulating factor receptor (GCSFR), Interleukin-6/-11/LIF/OSM/CNTF common beta chain (Gp130), Leukemia inhibiting factor receptor (LIFR), Oncostatin-M receptor beta chain (OSMR), Interleukin-12 receptor beta-1 chain (IL12RB1), Interleukin-12 receptor beta-2 chain (IL12RB2).

A schematic representation of the structure of these receptors is shown below:

 
+-------+-------------------------+-----------------xxxxxxx-----------------+
|Ig-like| C C  C  C Extracellular |    FnIII (x3)   XXXXXXX   Cytoplasmic   |
+-------+-|-|--|--|---------------+-----------------xxxxxxx-----------------+
          | |  |  |                              Transmembrane
          +-+  +--+
 

These receptor chains homodimerize (GCSFR, Gp130, LPTR) or heterodimerize (Gp130 with LIFR or OSMR, IL12RB1 with IL12RB2) upon binding of the cognate cytokine: G-CSF, LIF, OSM, LPT, or the cytokine/alpha chain complex: IL-6/IL6RA, IL-11/IL11RA, CNTF/CNTFRA, IL-12 (p35/p40) [PMID: 8293462,PMID: 8943050].

GO terms

Biological Process

No terms assigned in this category.

Molecular Function

GO:0004896 cytokine receptor activity

Cellular Component

GO:0016020 membrane

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
PROSITE patterns