Family

Phospho-N-acetylmuramoyl-pentapeptide transferase (IPR003524)

Short name: PNAcMuramoyl-5peptid_Trfase

Family relationships

Description

Phospho-N-acetylmuramoyl-pentapeptide-transferase (EC:2.7.8.13) (MraY) is a bacterial enzyme responsible for the formation of the first lipid intermediate of the cell wall peptidoglycan synthesis [PMID: 10564498]. It catalyses the formation of undecaprenyl-pyrophosphoryl-N-acetylmuramoyl-pentapeptide from UDP-MurNAc-pentapeptide and undecaprenyl-phosphate.

MraY is an integral membrane protein with probably ten transmembrane domains. It belongs to family 4 of glycosyl transferases. Homologues of MraY have been found in archaebacteria Methanobacterium thermoautotrophicum and in Arabidopsis thaliana (Mouse-ear cress).

GO terms

Biological Process

No terms assigned in this category.

Molecular Function

GO:0008963 phospho-N-acetylmuramoyl-pentapeptide-transferase activity

Cellular Component

GO:0016020 membrane

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
CDD
HAMAP
TIGRFAMs