Transcription factor COE (IPR003523)

Short name: Transcription_factor_COE

Overlapping homologous superfamilies

Family relationships



The independent cloning of rodent EBF/Olf-1 and Drosophila melanogaster Collier has defined a family of transcription factors, the Collier or COE family [PMID: 10477305]. COE proteins have various functions in different organisms.

In mouse, COE1 has a role in B-cell differentiation, and could also perform a role in neuronal differentiation. All three COE are expressed in immature olfactory neuronal precursors and mature olfactory neurons as well as in developping nervous system during embryogenesis.

In Drosophila, Collier is involved in the formation of the embryonic somatic muscle DA3, in the patterning of the wing by mediating Hedgehog activity. It could also act as a second-level regulator in the patterning of embryonic head.

GO terms

Biological Process

GO:0006355 regulation of transcription, DNA-templated

Molecular Function

GO:0003677 DNA binding

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.