Family

ICln (IPR003521)

Short name: ICln

Overlapping homologous superfamilies

None.

Family relationships

Description

ICln, known as methylosome subunit pICln or chloride conductance regulatory protein ICln, owes these different names to its function in multiple regulatory pathways [PMID: 16734741] as different as ion permeation, ribonucleoprotein biosynthesis and cytoskeletal organisation [PMID: 9556550]. ICln can be identified both in the cytosol and in the cellular membrane, where it functions as a chloride current regulator and is important in regulating volume decrease after cellular swelling [PMID: 20573047, PMID: 15760659, PMID: 17138647, PMID: 19471107].

pLCln also functions as a Sm chaperone in the stepwise snRNP assembly process [PMID: 11747828]. snRNPs is a RNA-protein complex esessential to the removal of introns from pre-mRNA [PMID: 19520849, PMID: 10330151]. In humans, the core of snRNPs is composed of seven Sm proteins bound to snRNA. pLCln tethers the hetero-oligomers SmD1/D2 and SmE/F/G into a ring-shaped 6S complex, which subsequently docks onto the SMN complex. The SMN complex then removes pICln and enables the transfer of pre-assembled Sm proteins onto snRNA [PMID: 23333303]. Consistent with the role of human pICln, the orthologue from S. pombe is required for optimal production of the spliceosomal snRNPs and for efficient splicing [PMID: 24298023].

GO terms

Biological Process

GO:0006884 cell volume homeostasis
GO:0006821 chloride transport
GO:0000387 spliceosomal snRNP assembly

Molecular Function

No terms assigned in this category.

Cellular Component

GO:0005829 cytosol
GO:0034709 methylosome
GO:0034715 pICln-Sm protein complex
GO:0005886 plasma membrane

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
PRINTS