Family

Salmonella plasmid virulence SpvA (IPR003518)

Short name: Sal_SpvA

Overlapping homologous superfamilies

None.

Family relationships

Description

Salmonella typhimurium contains a 90kb plasmid that is associated with virulence. This plasmid encodes at least 6 genes needed by the bacterium for invading host macrophages during infection. These include the 70kDa mkaA protein [PMID: 2164511], a recognised virulence factor, and more recently described, four spv genes under the control of a regulator [PMID: 8483415].

Deletion studies on the virulence plasmid have shown that an open reading frame encoding a 28kDa protein was needed for successful invasion of the host. This protein, designated mkfA [PMID: 2164511], VRP4 [PMID: 2696057] or VirA [PMID: 1657882] by different groups, is utilised by the microbe upon entry into macrophages, although the exact mechanism is unclear.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
PRINTS