Family

Fanconi anaemia group A protein (IPR003516)

Short name: FANCA

Overlapping homologous superfamilies

None.

Family relationships

None.

Description

Fanconi anemia (FA) is a human disorder characterized by cancer susceptibility and cellular sensitivity to DNA crosslinks and other damages. The FA complex repairs the interstrand cross-linking (ICL) lesions and coordinates activities of the downstream DNA repair pathway including nucleotide excision repair, translesion synthesis, and homologous recombination. It is required for the monoubiquitylation of FANCD2 and FANCI heterodimer. The FA core complex consists of FANCA, FANCB, FANCC, FANCE, FANCF, FANCG, FANCL, FANCM, FANCT (UBET2), FAAP100 and FAAP24 [PMID: 29017571, PMID: 20347428].

This entry represents FANCA [PMID: 29017571].

GO terms

Biological Process

GO:0036297 interstrand cross-link repair

Molecular Function

No terms assigned in this category.

Cellular Component

GO:0043240 Fanconi anaemia nuclear complex

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
Pfam
PRINTS
PANTHER