Fumarate reductase, subunit C (IPR003510)

Short name: Fumarate_red_C

Overlapping homologous superfamilies

Family relationships



Fumarate reductase is a membrane-bound flavoenzyme consisting of four subunits, A-D. A and B comprise the membrane-extrinsic catalytic domain and C and D link the catalytic centres to the electron-transport chain. This family consists of the 15kDa hydrophobic subunit C. Members of this subfamily are classified as Type D as they contain two transmembrane subunits (C and D) and no heme groups. The structural arrangement allows efficient electron transfer between the catalytic subunit, through iron-sulfur centres, and the transmembrane subunit containing the electron donor (quinol). The quinone binding site resides in the transmembrane subunits.

Quinol:fumarate reductase (QFR) couples the reduction of fumarate to succinate to the oxidation of quinol to quinone, the opposite reaction to that catalyzed by the related protein, succinate:quinine oxidoreductase (SQR). QFRs oxidize low potential quinols such as menaquinol and are involved in anaerobic respiration with fumarate as the terminal electron acceptor. SQR and QFR share a common subunit arrangement, composed of a flavoprotein catalytic subunit, an iron-sulfur protein and one or two hydrophobic transmembrane subunits [PMID: 10373108, PMID: 11850430, PMID: 3308458, PMID: 15654871, PMID: 15884941, PMID: 11803023, PMID: 10486141, PMID: 11803024, PMID: 9210286, PMID: 15078221, PMID: 11004459].

GO terms

Biological Process

No terms assigned in this category.

Molecular Function

No terms assigned in this category.

Cellular Component

GO:0016020 membrane

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.