CobW/HypB/UreG, nucleotide-binding domain (IPR003495)

Short name: CobW/HypB/UreG_dom

Overlapping homologous superfamilies

Domain relationships



This domain is found in HypB, a hydrogenase expression/formation protein, and urease accessory protein UreG. Both these proteins contain a P-loop nucleotide binding motif [PMID: 9209019, PMID: 8423137]. HypB has GTPase activity and is a guanine nucleotide binding protein [PMID: 8423137]. UreG is a GTPase in charge of nucleotide hydrolysis required for activation of the urease enzyme [PMID: 25846143]. Both GTPases are involved in nickel binding. HypB can store nickel and is required for nickel dependent hydrogenase expression [PMID: 9140970]. UreG is required for functional incorporation of the urease nickel metallocentre [PMID: 1624427]. GTP hydrolysis may required by these proteins for nickel incorporation into other nickel proteins [PMID: 9140970].

Other proteins containing this domain include P47K (P31521), a Pseudomonas chlororaphis protein needed for nitrile hydratase expression, CobW (P29937), which may be involved in cobalamin biosynthesis in Pseudomonas denitrificans [PMID: 1655697], and YjiA [PMID: 14696199]. Both CobW and YjiA are members of the metal homeostasis-associated COG0523 family of GTPases [PMID: 24449932].

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.