Ribosome hibernation promoting factor/RaiA (IPR003489)

Short name: RHF/RaiA

Overlapping homologous superfamilies

Family relationships


This family consists of ribosome hibernation promoting factor (RHF). RHF promotes and stabilizes dimerization of 70S ribosomes by the ribosome modulation factor (RMF), leading to the formation of inactive 100S ribosomes during the stationary phase [PMID: 18174192].

This family also includes RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY). This is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal A site [PMID: 15502846]. RaiA is also thought to counteract miscoding at the A site thus reducing translation errors [PMID: 15219834]. The RaiA fold structurally resembles the double-stranded RNA-binding domain (dsRBD) [PMID: 12392550].

GO terms

Biological Process

GO:0044238 primary metabolic process

Molecular Function

No terms assigned in this category.

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.