DNA recombination-mediator protein A (IPR003488)

Short name: DprA

Overlapping homologous superfamilies


Family relationships



This family of bacterial proteins includes DNA processing protein A (DprA) from Streptococcus pneumoniae and Smf, the Bacillus subtilis orthologue. DprA is a new member of the recombination-mediator protein family, dedicated to natural bacterial transformation [PMID: 17803906]. In Helicobacter pylori, DprA is required for natural chromosomal and plasmid transformation [PMID: 10640603]. It has now been shown that DprA binds cooperatively to single-stranded DNA (ssDNA) and interacts with RecA. In the process, DprA-RecA-ssDNA filaments are produced and these filaments catalyse the homology-dependent formation of joint molecules. While the Escherichia coli SSB protein limits access of RecA to ssDNA, DprA alleviates this barrier [PMID: 17803906]. DprA has a role not only in ensuring production of transformants via interaction with RecA, it is also involved in competence shut-off via interaction with ComE [PMID: 23440217].

GO terms

Biological Process

GO:0009294 DNA mediated transformation

Molecular Function

No terms assigned in this category.

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.