Family

Monooxygenase component MmoB/DmpM (IPR003454)

Short name: mOase_MmoB_DmpM

Overlapping homologous superfamilies

Family relationships

None.

Description

This entry represents a family of monooxygenase components that include methane monooxygenase (EC:1.14.13.25) regulatory protein B (MmoB), and Phenol hydroxylase (EC:1.14.13.7) protein component P2 (DmpM). When MmoB is present at low concentration it converts methane monooxygenase from an oxidase to a hydroxylase and stabilises intermediates required for the activation of dioxygen [PMID: 10393915]. DmpM lacks redox co-factors and is required for optimal turnover of Phenol hydroxylase [PMID: 9012665]. Phenol hydroxylase catabolises phenol and some of its methylated derivatives in the first step of phenol biodegradation, and is required for growth on phenol. The multicomponent enzyme is made up of P0, P1, P2, P3, P4 and P5 polypeptides. This family also includes Propane 2-monooxygenase, effector component (MimD) which has been shown to function as a coupling protein in the multicomponent propane 2-monooxygenase enzyme system in the degradation of propane as well as the conversion of phenol to hydroquinone [PMID: 21183637]. Also included in this family is the effector component (TmoD) of the toluene-4-monooxygenase system (EC:1.14.13.236), from Pseudomonas mendocina which catalyzes the O2- and NADH-dependent hydroxylation of toluene to form p-cresol [PMID: 11297417], and the effector subunit of the alkene monooxygenase system (EC:1.14.13.69) from Xanthobacter autotrophicus, which catalyzes the O2- and NADH-dependent epoxidation of short chain (C2 to C6) alkenes to their corresponding epoxides [PMID: 9312093].

GO terms

Biological Process

GO:0006725 cellular aromatic compound metabolic process

Molecular Function

GO:0004497 monooxygenase activity

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
Pfam
ProDom