Stem cell factor (IPR003452)

Short name: SCF

Overlapping homologous superfamilies

Family relationships



Stem cell factor (SCF) is a homodimer involved in hematopoiesis. SCF binds to and activates KIT, a receptor tyrosine kinase [PMID: 17662946]. SCF stimulates the proliferation of mast cells and is able to augment the proliferation of both myeloid and lymphoid hematopoietic progenitors in bone marrow culture. It also mediates cell-cell adhesion and acts synergistically with other cytokines. SCF is a type I membrane protein, but is also found in a secretable, soluble form. The crystal structure of human SCF has been resolved and a potential receptor-binding site identified [PMID: 10884405].

GO terms

Biological Process

GO:0007155 cell adhesion

Molecular Function

GO:0005173 stem cell factor receptor binding

Cellular Component

GO:0016020 membrane

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.