tRNA threonylcarbamoyl adenosine modification protein TsaE (IPR003442)

Short name: T6A_TsaE

Family relationships


Members of this family have a conserved nucleotide-binding motif GXXGXGKT and a nucleotide-binding fold. Member protein YjeE of Haemophilus influenzae (HI0065) was shown to have ATPase activity [PMID: 12112691, PMID: 17581233]. The protein has a nucleotide-binding fold with a four-stranded parallel beta-sheet flanked by antiparallel beta-strands on each side. The topology of the beta-sheet is unique among P-loop proteins and has features of different families of enzymes. ADP has been shown to bind to the P-loop in the presence of Mg2+.

Recently YjeE has been renamed as TsaE [PMID: 22378793]. It is responsible for tRNA threonylcarbamoyl adenosine modification together with proteins TsaB, TsaC, and TsaD, and probably forms a complex with them [PMID: 22378793, PMID: 23072323].

GO terms

Biological Process

GO:0002949 tRNA threonylcarbamoyladenosine modification

Molecular Function

No terms assigned in this category.

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.