Glycosyl transferase, family 48 (IPR003440)

Short name: Glyco_trans_48

Overlapping homologous superfamilies


Family relationships


The biosynthesis of disaccharides, oligosaccharides and polysaccharides involves the action of hundreds of different glycosyltransferases. These enzymes catalyse the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. A classification of glycosyltransferases using nucleotide diphospho-sugar, nucleotide monophospho-sugar and sugar phosphates (EC:2.4.1.-) and related proteins into distinct sequence based families has been described [PMID: 9334165]. This classification is available on the CAZy (CArbohydrate-Active EnZymes) web site. The same three-dimensional fold is expected to occur within each of the families. Because 3-D structures are better conserved than sequences, several of the families defined on the basis of sequence similarities may have similar 3-D structures and therefore form 'clans'.

This is the glycosyltransferase 48 family GT48, which consists of various 1,3-beta-glucan synthase components including Gls1, Gls2 and Gls3 from yeast. 1,3-beta-glucan synthase (EC: also known as callose synthase catalyses the formation of a beta-1,3-glucan polymer that is a major component of the fungal cell wall [PMID: 9209021]. The reaction catalysed is:-

UDP-glucose + {1,3-beta-D-glucosyl}(N) = UDP + {1,3-beta-D-glucosyl}(N+1).

GO terms

Biological Process

GO:0006075 (1->3)-beta-D-glucan biosynthetic process

Molecular Function

GO:0003843 1,3-beta-D-glucan synthase activity

Cellular Component

GO:0000148 1,3-beta-D-glucan synthase complex
GO:0016020 membrane

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.